C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/566.1, 260/4
C07D 263/08 (2006.01) C07C 1/34 (2006.01) C07C 13/48 (2006.01) C07C 29/143 (2006.01) C07C 33/34 (2006.01) C07C 43/168 (2006.01) C07C 45/63 (2006.01) C07C 45/64 (2006.01) C07C 47/548 (2006.01) C07C 49/792 (2006.01) C07C 49/798 (2006.01) C07C 49/813 (2006.01) C07C 49/84 (2006.01) C07C 63/66 (2006.01) C07D 263/12 (2006.01) C07D 265/30 (2006.01) C07D 279/12 (2006.01) C07D 295/185 (2006.01) C07D 317/12 (2006.01) C07F 9/54 (2006.01)
Patent
CA 1123839
ABSTRACT This invention is concerned with compounds of the general formula Image (I) wherein n stands for 1 or 2 and, when n stands for 1, R1 and R2 represent hydrogen, lower alkoxy or halogen, or, when n stands for 2, R1 represents hydrogen, lower alkoxy or halogen and R2 represents hydrogen; R3, R4, R5 and R6 represent hydrogen or lower alkyl; R7 represents hydrogen, methyl or ethyl; R8 and R9 represent hydrogen, lower alkyl or halogen; and R10 represents a group of the formula -(CH=CR19)mR11, in which m stands for zero or 1 and R11 represents a group of the formula Image or Image or the 2-oxazolinyl group, or, when m stands for 1, also represents hydrogen; R12 represents hydrogen or lower alkyl; R13 represents hydrogen, lower alkyl of a group of the formula -N(R17,R18) or -OR14; R14 represents hydrogen, lower alkyl or alkanoyl; R15 represents hydrogen, lower alkyl or a group of the formula -OR16 or -(CH2)pN(R17, R18) R16 represents hydrogen, lower alkyl, hydroxy-(lower alkyl), aryl, substituted aryl, aralkyl or aralkyl substituted in the aryl portion; R17 and R18 represent hydrogen or lower alkyl or R17 and R18 together with the nitxogen atom to which they are attached represent a heterocyclic group; R19 represents hydroqen or lower alkyl and p stands for zero, 1, 2 or 3; as well as ketals of compounds of formula I in which R11 represents a group of the formula -C(O)R15 and R15 represents hydroqen or lower alkyl, and salts of c????unds of formula I. The invention is also concerned w??? process for the manufacture of these com- pounds and salts and with pharmaceutical preparations con- taining them. Tha compounds of formula I and their salts are useful for the treatment of neoplasms, dermatological conditions and rheumatic diseases.
317610
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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