Stilbenes and chalcones for the prevention and treatment of...

A - Human Necessities – 61 – K

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A61K 31/166 (2006.01) A61K 31/05 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 31/216 (2006.01) A61K 31/265 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2584485

The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

La présente invention concerne des composés de polyphénol n'existant pas à l'état naturel qui régulent à la hausse l'expression de l'apolipoprotéine A-I (ApoA-I). Les compostions et méthodes de l'invention conviennent pour le traitement et la prévention de maladies cardio-vasculaires et manifestations pathologiques connexes dont les troubles dus à un excès de cholestérol ou de lipides tels que l'athérosclérose.

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