Stimulated monocyte derived cells, their preparation and uses

Details Stimulated monocyte derived cells, their preparation and uses Stimulated monocyte derived cells, their preparation and uses

C - Chemistry, Metallurgy

12

N

C12N 5/0786 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2320491

The invention relates to stimulated monocyte derived cells presenting the following characteristics: 1) increased release, with respect to normal monocyte derived cells, of for instance PDGF (platelet derived growth factor), and increased presence, on their membranes, with respect to normal monocyte derived cells, of for instance CD1.alpha., and/or: 2) presence in their nucleus of at least one exogenous nucleic acid which has been integrated in the absence of the monocyte derived cell division. These stimulated monocyte derived cells can be the active substance of pharmaceutical compositions.

L'invention concerne des cellules dérivées de monocytes stimulés, présentant les caractéristiques suivantes: 1) dégagement accru, par rapport aux cellules dérivées de monocytes normales, par exemple, de PDGF (facteur de croissance d'origine plaquettaire); et présence accrue, sur leur membrane, par rapport aux cellules dérivées de monocytes normales, par exemple, de CD1.alpha.; et/ou 2) présence dans leur noyau d'au moins un acide nucléique exogène ayant été intégré en l'absence de division des cellules dérivées de monocytes. Ces cellules dérivées de monocytes stimulés peuvent constituer la substance active de compositions pharmaceutiques.

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