Stimulating factor of the neu receptor

Details Stimulating factor of the neu receptor Stimulating factor of the neu receptor

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 14/475 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2063239

ABSTRACT OF THE DISCLOSURE STIMULATING FACTOR OF THE neu RECEPTOR The neu proto-oncogene encodes a transmembrane glycoprotein related to the receptor for epidermal growth factor (EGF). Purification of a stimulating factor for the neu receptor to homogeneity from ras- transformed fibroblasts has now been achieved. Its identity as a neu receptor stimulating factor has been established by covalent crosslinking experiments. The factor stimulates the tyrosine phosphorylation of the neu receptor at low concentrations. The factor inhibits the proliferation and promotes the differentiation of human carcinoma cells.

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