A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 35/32 (2006.01) A61L 27/12 (2006.01) A61L 27/18 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01) A61L 27/46 (2006.01) A61L 27/50 (2006.01) A61P 19/00 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2511257
Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction or cartilage repair. The method comprises the step of administering a therapeutically effective amount of an agonist of the non- proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondroxytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
L'invention concerne une méthode pour stimuler la croissance osseuse sur un site d'un patient nécessitant une ostéoinduction ou une réparation du cartilage. Cette méthode consiste à administrer sur ledit site une quantité thérapeutiquement efficace d'un agoniste du récepteur de la thrombine activé de manière non-protéolytique. La présente invention porte également sur une méthode pour stimuler la prolifération et l'expansion de chondrocytes in vitro, cette méthode consistant à cultiver des chondrocytes en présence d'une quantité stimulante d'un agoniste NPAR.
Bergmann John
Carney Darrell H.
Crowther Roger S.
Redin William R.
Simmons David J.
Borden Ladner Gervais Llp
The Board Of Regents The University Of Texas System
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