C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 35/32 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 38/48 (2006.01) A61L 27/14 (2006.01) A61L 27/18 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) A61P 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2416404
Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
L'invention concerne un procédé de stimulation de croissance, de réparation et de régénération du cartilage, sur un site d'un sujet nécessitant de tels actions. Ce procédé consiste à administrer une quantité thérapeutiquement efficace d'un agoniste du récepteur de la thrombine activé non-protéolitiquement sur le site. L'invention concerne également un procédé de stimulation de la prolifération et de l'expansion de chrondrocytes <i>in vitro</i>. De plus, ce procédé permet de cultiver des chrondrocytes en présence d'une quantité stimulante d'un agoniste NPAR .
Bergmann John
Carney Darrell H.
Crowther Roger S.
Stiernberg Janet
Borden Ladner Gervais Llp
The Board Of Regents The University Of Texas System
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