Stimulation of cpt-1 as a means to reduce weight

Details Stimulation of cpt-1 as a means to reduce weight Stimulation of cpt-1 as a means to reduce weight

A - Human Necessities

61

K

A61K 31/365 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/205 (2006.01) A61K 31/336 (2006.01) A61K 31/34 (2006.01) A61K 31/381 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2474884

This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase - 1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.

L'invention concerne des procédés et des compositions qui induisent une perte de poids corporel et maintiennent un poids corporel optimal. Ces procédés consistent à administrer un agent qui stimule l'activité de la carnitine palmitoyl transférase 1 (CPT-1) à un sujet humain. Ces procédés ne nécessitent pas d'inhibition de la synthèse d'acides gras. En particulier, l'invention traite de procédés pour le développement de la thérapeutique qui améliore de manière sélective l'oxydation d'acides gras, augmente la production d'énergie et réduit l'adiposité tout en conservation la masse musculaire par le biais de la stimulation pharmacologique de l'activité de la CPT-1. Selon un mode de réalisation préféré, l'agent est administré selon une quantité suffisante pour augmenter l'oxydation des acides gras. Selon un autre mode préféré, l'agent est administré selon une quantité suffisante pour antagoniser l'inhibition de malonyl CoA de CPT-A. Dans encore un autre mode préféré, l'agent est administré selon une quantité suffisante pour augmenter la concentration de malonyl CoA.

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