C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/06 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2611002
This invention provides a polypeptide, TMEM27, and secreted forms thereof, nucleic acids and constructs encoding the same, and cells comprising the same. The TMEM27 protein is expressed in hormone positive cells at early stages of pancreas development and pancreatic .beta.-cells in the mature pancreas, whose expression promotes pancreatic .beta.-cell replication and increased islet mass. Applications of the protein in diagnostics and therapeutics are described.
L'invention concerne un polypeptide, TMEM27, et des formes sécrétées de celui-ci, des acides nucléiques et des constructions codant pour le polypeptide et des cellules comprenant ce polypeptide. La protéine TMEM27 est exprimée dans des cellules à hormone positive à des stades précoces du développement du pancréas et dans des lymphocytes pancréatiques ß dans un pancréas mûr, dont l'expression favorise la réplication des lymphocytes pancréatiques ß et augmente la masse d'îlots. L'invention concerne également des applications de la protéine dans des diagnostics et des thérapies.
Akpinar Pinar
Stoffel Markus
Smart & Biggar
The Rockefeller University
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