A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/53 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2352783
Stimulation of T cells to respond to self antigens is achieved through a blockade of CTLA-4 signaling. CTLA-4 blocking agents are combined with antigen preparations, either alone or with additional immune response stimulating agents, in costimulation strategies to break immune tolerance and stimulate an enhanced T-cell response against self antigens. This enhanced response is useful for the treatment of non-immunogenic and poorly-immunogenic tumors, as well as other medical conditions requiring selective tissue ablation.
La stimulation de lymphocytes T en réponse à des auto-antigènes s'obtient par blocage au moyen de la signalisation CTLA-4. On combine des agents bloquants CTLA-4 avec des préparations antigéniques, soit seuls, soit avec d'autres agents stimulant la réponse immunitaire, dans le cadre de stratégies de co-stimulation pour rompre la tolérance immunitaire et stimuler et accentuer la réponse des lymphocytes T contre les auto-antigènes. Cette réponse plus marquée est utile pour le traitement de tumeurs non immunogènes ou faiblement immunogènes ainsi que pour diverses pathologies nécessitant l'ablation sélective de tissus.
Allison James P.
Hurwitz Arthur A.
Vanelsas Andrea
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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