Stimulatory auto-antibodies to the pdgf receptor as...

G - Physics – 01 – N

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G01N 33/564 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2616963

An in vitro method for detecting the presence in a body sample of auto- antibodies for the PDGF receptor suitable for the diagnosis and prognosis of autoimmune diseases, in particular the systemic sclero-is and related diagnostic kits. Use of an inhibitor of ROS and/or Ras-ERK1/2 for the preparation of a medicament for therapeutic treatment of autoimmune diseases or of treating the Graft-Versus-Host- Reaction (GVHR). Pharmaceutical composition comprising an effective amount of an inhibitor of ROS and/or Ras- ERK1/2, and proper diluents, and /or excipients, and/or adjuvants.

L'invention porte sur une technique in vitro de détection de la présence, dans un échantillon du corps humain, d'auto-anticorps du récepteur PDGF convenant au diagnostic et au pronostic de maladies autoimmunes, en particulier de la sclérodermie systémique, ainsi que sur des kits diagnostics associés. L'invention porte également sur un inhibiteur de ROS et/ou de Ras-ERK1/2 utilisé dans la préparation d'un médicament destiné au traitement thérapeutique de maladies autoimmunes ou destiné au traitement des formes de réaction du greffon contre l'hôte (GVHR). L'invention porte également sur une composition pharmaceutique comprenant une dose efficace d'un inhibiteur de ROS et/ou de Ras-ERK1/2, de diluants appropriés, et/ou d'excipients et/ou d'adjuvants.

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