Stimuli-responsive hydrogel

Details Stimuli-responsive hydrogel Stimuli-responsive hydrogel

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/06 (2006.01) A61K 38/19 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2726949

The present invention relates to a hydrogel comprising a polymer, a first polypeptide and a polypeptide binding partner, wherein the polypeptide binding partner is a second polypeptide, a nucleic acid or a small molecule, and wherein the interaction between the first polypeptide and the polypeptide binding partner stabilizes the hydrogel and is modulated by the addition of a modulating compound. A drug may be physically entrapped in the hydrogel, bound to the polymer forming the hydrogel structure, or bound to the first polypeptide or the polypeptide binding partner, and then be set free on addition of the modulating compound. Such a hydrogel comprising a drug may be injected into a patient, and drug release modulated by orally administering the modulating compound.

La présente invention porte sur un hydrogel comprenant un polymère, un premier polypeptide et un partenaire de liaison au polypeptide, le partenaire de liaison au polypeptide étant un second polypeptide, un acide nucléique ou une petite molécule, et linteraction entre le premier polypeptide et le partenaire de liaison au polypeptide stabilisant lhydrogel et étant modulée par laddition dun composé de modulation. Un médicament peut être physiquement piégé dans lhydrogel, lié au polymère formant la structure de lhydrogel, ou lié au premier polypeptide ou au partenaire de liaison au polypeptide, puis être libéré par laddition du composé de modulation. Un tel hydrogel comprenant un médicament peut être injecté dans un patient, et la libération de médicament modulée par administration par voie orale du composé de modulation.

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