Stimulus-inducible i (kappa)b kinase [ikk] signalsome

Details Stimulus-inducible i (kappa)b kinase [ikk] signalsome Stimulus-inducible i (kappa)b kinase [ikk] signalsome

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2263835

Compositions and methods are provided for treating NF-B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-B activation.

Cette invention se rapporte à des compositions et à des procédés permettant de traiter des troubles liés au facteur nucléaire NF-?B. Elle se rapporte notamment à un agent caractérisé par un signal IKK inductible par stimulus, et à des composants et des variants de cet agent. On peut utiliser un agent caractérisé par un signal IKK ou un de ses composants pour identifier, par exemple, des anticorps et autres agents de modulation qui inhibent ou activent la transduction de signaux par l'intermédiaire de la cascade NF-?B. On peut également utiliser l'agent caractérisé par un signal IKK, ses composants et/ou des agents de modulation pour traiter des maladies associées à une activation du facteur NF-?B.

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