Stimulus-responsive apta-chelamers

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 9/09 (2006.01) A61K 31/198 (2006.01) A61K 31/683 (2006.01) C07D 235/00 (2006.01) C07D 235/04 (2006.01)

Patent

CA 2730083

Disclosed are apta-chelamers comprising aptamer domains tethered to rationally designed synthetic protein-binding modules, and methods of designing and making the same. Also disclosed are stimulus-responsive apta-chelamers capable of simultaneously or sequentially binding (and, thus, inhibiting) two protein targets.

L'invention concerne des apta-chélamères qui comportent des domaines d'aptamère reliés à des molécules de liaison à une protéine synthétique conçue rationnellement, et des procédés de conception et de réalisation de ceux-ci. L'invention concerne également des apta-chélamères sensibles à un stimulus capables de se lier simultanément ou séquentiellement à deux protéines cibles (et ainsi d'inhiber celles-ci).

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