Stimulus sensitive gel with radioisotope and methods of making

Details Stimulus sensitive gel with radioisotope and methods of making Stimulus sensitive gel with radioisotope and methods of making

A - Human Necessities

61

K

A61K 51/06 (2006.01) A61K 51/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2327325

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of a [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclide carrier has the steps of: (a) mixing a stimulus- sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

La présente invention concerne un gel sensible aux stimuli et thermiquement réversible ou un transporteur radio-isotope copolymère gélifiant qui est un copolymère aléatoire linéaire d'un dérivé de (méth-)acrylamide et un comonomère hydrophile. Le copolymère aléatoire linéaire se présente sous la forme de plusieurs chaînes linéaires ayant plusieurs poids moléculaires supérieurs ou égaux à un seuil de rétention minimum des molécules de gélification. L'addition d'un squelette biodégradable et/ou d'un agent thérapeutique confère une autre utilité. Le procédé selon la présente invention permet de produire un transporteur radionucléide copolymère gélifiant sensible aux stimuli et thermiquement réversible et consiste à: (a) mélanger un copolymère gélifiant réversible sensible aux stimuli à un solvant aqueux sous la forme de solution gélifiante réversible sensible aux stimuli; et (b) à mélanger un radioisotope à cette solution gélifiante réversible sensible aux stimuli comme ledit transporteur radioisotope. Le gel est amélioré l'association d'un squelette biodégradable et/ou d'un agent thérapeutique d'une solution gélifiante obtenue par mélange du copolymère à un solvant aqueux.

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