Storage stable tretinoin and 4-hydroxy anisole containing...

Details Storage stable tretinoin and 4-hydroxy anisole containing... Storage stable tretinoin and 4-hydroxy anisole containing...

A - Human Necessities

61

K

A61K 8/67 (2006.01)

Patent

CA 2419877

A long-term storage stable tretinoin and 4-hydroxyanisole composition contains low molecular weight polyethylene glycol, antioxidant, a chelating agent, lower alkanol and water. The chelating agent provides at least two of the functions of oxygen scavaging, free radical chain terminating and reducing. The composition has a pH of 2.5 to 5 and a water content of at least 12%.

La présente invention concerne une composition de trétinoïne et de 4-hydroxy anisole stable au stockage de longue durée qui contient un polyéthylène glycol de faible poids moléculaire, un antioxydant, un agent chélateur, un alcanol inférieur et de l'eau. L'agent chélateur assure au moins deux des fonctions suivantes : désoxygénation, terminaison de la chaîne des radicaux libres et réduction. La composition de l'invention possède un pH compris entre 2,5 et 5 et une teneur en eau d'au moins 12 %.

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