C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/19 (2006.01) C07K 14/705 (2006.01) C12N 15/81 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2117616
A modified Saccharomyces cerevisiae cell, wherein the cell expresses minK but does not express TRK1 and TRK2. Also disclosed is a process for detecting modulators of minK, which comprises (a) treating such modified Saccharomyces cerevisiae cells with a test compound, (b) assessing growth in the presence of a test compound and (c) determining an increase or decrease in potassium uptake into the Saccharomyces cerevisiae cells. MinK inhibitors are useful anti-arrhythmic or antifibrillatory agents; activators, anti-ischemic agents.
Knickerbocker Aron M.
Kurtz Stephen E.
Mccullough John R.
Knickerbocker Aron M.
Kurtz Stephen E.
Mccullough John R.
Osler Hoskin & Harcourt Llp
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