Streptococcal abc transporter protein

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/09 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12N 15/63 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2357996

A polypeptide suitable for use in vaccination against Streptococcal infections comprises: a) the amino acid sequence of SEQ ID No 1; b) a variant of (a) which is capable of binding an anti-MtsA antibody; or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of binding an anti- MtsA antibody. A vaccine composition comprises: a) the amino acid sequence of SEQ ID No 1; b) a variant of (a) which is capable of generating an immune response to a Streptococcal; or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of generating an immune response against a Streptococcus.

Cette invention concerne un polypetide dont l'emploi convient pour la vaccination contre des infections streptococciques et qui comprend: (a) une séquence d'acides aminés de SEQ ID NO1; (b) une variante de (a) capable de se lier avec un anticorps anti-MtsA; ou (c) un fragment de (a) ou de (b) d'au moins 6 acides aminés d'une longueur suffisante pour se lier avec un anticorps anti-MtsA. Une composition de vaccin comprend: (a) la séquence d'acides aminés de SEQ ID NO 1; (b) une variante de (a) capable de déclencher une réponse immunitaire à un streptocoque; ou (c) un fragment de (a) ou (b) d'au moins 6 acides aminés d'une longueur appropriée pour déclencher une réponse immunitaire contre un streptocoque.

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