Streptococcal c beta protein compositions

Details Streptococcal c beta protein compositions Streptococcal c beta protein compositions

C - Chemistry, Metallurgy

12

N

C12N 1/06 (2006.01) A01N 43/04 (2006.01) A61K 38/00 (2006.01) A61K 39/02 (2006.01) A61K 39/09 (2006.01) A61K 39/116 (2006.01) A61K 39/385 (2006.01) A61K 45/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12N 1/12 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2343051

The invention relates to protein fragments or peptides that elicit antibodies to Gram positive bacteria which are bactericidal with complement alone without involving an opsonophagocytic mechanism, and to vaccines and conjugates comprising the same. The protein fragments or peptides comprise an immunogenic IgG binding domain, which comprises a peptide sequence of at least 8 amino acids between positions 828 and 1027 of the amino acid sequence shown in Fig. 1. The invention also relates to a polynucleotide molecule encoding the protein fragments or peptides, vectors comprising such polynucleotide molecules and host cells transformed therewith. The invention relates to a process for obtaining a substantially pure C beta protein or fragment and/or mutant thereof. The invention also relates to a method of inducing an immune response in an animal, comprising administering the vaccine of the invention to an animal in a therapeutically effective amount in a pharmaceutically acceptable carrier.

L'invention concerne des peptides ou fragments protéiques produisant des anticorps bactéricides de bactéries de Gram positif avec complément seulement, ne provoquant pas un mécanisme opsonophagocytaire, et des vaccins et conjugués comprenant lesdits peptides ou fragments. Ces peptides ou fragments protéiques comportent un domaine immunogène de liaison IgG, présentant une séquence peptidique d'au moins 8 acides aminés entre les positions 828 et 1027 de la séquence d'acides aminés de la figure 1. Cette invention a également trait à une molécule polynucléotidique codant pour ces peptides ou fragments protéiques, à des vecteurs comprenant ces molécules polynucléotidiques, et à des cellules hôtes ainsi transformées. Ladite invention concerne un processus permettant d'obtenir une protéine C bêta pratiquement pure ou un fragment et/ou mutant de celle-ci, ainsi qu'une technique permettant de provoquer une réponse immunitaire chez un animal, qui consiste à administrer un vaccin de cette invention à un animal en quantité thérapeutiquement efficace dans un excipient acceptable sur le plan pharmaceutique.

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