Streptococcal heat shock proteins members of the hsp70 family

Details Streptococcal heat shock proteins members of the hsp70 family Streptococcal heat shock proteins members of the hsp70 family

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/09 (2006.01) A61K 39/40 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2224015

Novel heat shock proteins (HSPs) of Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae having apparent molecular masses of 70- 72 kDa, immunologically related polypeptides, the nucleotide and derived amino acid sequences of HSP72 of S. pneumoniae (SEQ ID NO:4; SEQ ID NO:5), the nucleotide and derived amino acid sequences of HSP70 of S. pyogenes (SEQ ID NO:19; SEQ ID NO:20), the nucleotide and derived amino acid sequences of HSP 70 of S. agalactiae (SEQ ID NO:21; SEQ ID NO:22), antibodies that bind to the HSPs, and recombinant DNA methods for the production of the HSPs and immunologically related polypeptides are described. The polypeptides, DNA sequences and antibodies of this invention provide new means for the diagnosis, prevention and/or treatment of Streptococcal disease.

L'invention concerne des protéines de choc thermique du Streptococcus pneumoniae, du Streptococcus pyogenes et du Streptococcus agalactiae de masse moléculaire apparente comprise entre 70 et 72 kDa, les polypeptides qui leur sont apparentés du point de vue immunologique, les séquences de nucléotides et d'acides aminés dérivés de la famille 72 des protéines de choc thermique de S. pneumoniae (SEQ ID no. 4, SEQ ID No. 5), les séquences de nucléotides et d'acides aminés dérivés de la famille 70 des protéines de choc thermique de S. pyogenes (SEQ ID No. 19, SEQ ID No. 20), les séquences de nucléotides et d'acides aminés dérivés de la famille 70 des protéines de choc thermique de S. agalactiae (SEQ ID No. 21, SEQ, ID No 22), les anticorps qui se lient aux protéines de choc thermique, ainsi que des procédés de recombinaison d'ADN utiles pour produire ces protéines de choc thermique et les polypeptides qui leur sont apparentés du point de vue immunologique. Ces polypeptides, séquences d'ADN et anticorps constituent de nouveaux moyens de diagnostic, de prévention et/ou de traitement de maladies causées par des streptocoques.

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