Streptococcus pneumoniae pilus antigens

Details Streptococcus pneumoniae pilus antigens Streptococcus pneumoniae pilus antigens

C - Chemistry, Metallurgy

07

K

C07K 14/315 (2006.01) A61K 39/09 (2006.01) C07K 16/12 (2006.01) C12N 9/10 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2688284

Polypeptides from Streptococcus pneumoniae are described. In some aspects the polypeptides include pili polypeptides from a second pili island (pilus II island (INVl 04B)) identified in Streptococcus pneumoniae isolate INVl 04. In other aspects the polypeptides include pili polypeptides and non-pilus polypeptides from Streptococcus pneumoniae strains 23F, INV200, and OXC141 that are absent from Streptococcus pneumoniae isolate INV104. The polypeptides, including fragments and variants thereof, may be used in immunogenic compositions for prophylactic or therapeutic immunization against Streptococcus pneumoniae. The polypeptides are also disclosed to be used in compositions useful for the production of antibodies and immunostimulants. Also presented are methods of inhibiting Streptococcus pneumoniae, methods of treating Streptococcus pneumoniae infection, methods of identifying inhibitors of Streptococcus pneumoniae and methods for diagnosing/detecting Streptococcus pneumoniae infection.

L'invention décrit des polypeptides provenant de Streptococcus pneumoniae. Sous certains aspects, les polypeptides comprennent des polypeptides de pili provenant d'un second îlot de pili (îlot de pilus II (INVl 04B)) identifié dans un isolat de Streptococcus pneumoniae INV1 04. Sous d'autres aspects, les polypeptides comprennent des polypeptides de pili et des polypeptides non pilus provenant de souches de Streptococcus pneumoniae 23F, INV200 et OXC141 absentes de l'isolat de Streptococcus pneumoniae INV104. Les polypeptides comprenant des fragments et des variantes de ceux-ci peuvent être utilisés dans des compositions immunogènes pour immunisation prophylactique ou thérapeutique contre Streptococcus pneumoniae. Les polypeptides peuvent également être utilisés dans des compositions utiles pour la production d'anticorps et d'immunostimulants. L'invention concerne également des procédés consistant à inhiber Streptococcus pneumoniae, à traiter une infection par Streptococcus pneumoniae, à identifier des inhibiteurs de Streptococcus pneumoniae et à diagnostiquer/détecter une infection par Streptococcus pneumoniae.

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