C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/39.1
C12N 15/58 (2006.01) C07K 14/315 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/70 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2020828
STREPTOKINASE PROTEINS, CORRESPONDING GENES, CORRESPONDING PLASMID RECOMBINANTS, CORRESPONDING TRANSFORMANTS AND PROCESSES FOR PREPARING SAME ABSTRACT OF THE DISCLOSURE : This invention relates to a novel chemically synthesized gene including a base sequence coding for the primary amino acid sequence of natutal-type streptokinase, a corresponding plasmid recombinant, corresponding transformant and process for preparing streptokinase by the incubation of the transformant, the invention further relating to novel streptokinase derivative proteins having streptokinase activity and a modified primary amino acid sequence corresponding to the primary amino acid sequence of natural-type streptokinase which is deficient in the amino acid residues at the 373-position to the C-terminal, and wherein at least one of the amino acid residue may be deficient, replaced or inserted, chemically synthesized gene including a base sequence coding for the derivative protein, plasmid recombinant containing the gene, transformant transformed by the recombinant, and process for preparing the streptokinase derivative protein by the incubation of the transformant.
Fujii Setsuro
Katano Tamiki
Majima Eiji
Ogino Koichi
Ono Kenji
Marks & Clerk
Otsuka Pharmaceutical Factory Inc.
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