C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) C12P 7/40 (2006.01) C12P 13/00 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2227924
The invention disclosed relates to the biological production of substantially isomerically pure (R)-baclofen and structurally related compounds, from the racemic mixture of (R)- and (S)-isomers thereof, and to the isolation of a Streptomyces microorganism from Nature which is capable of preferentially metabolizing one of the isomers while showing minimal metabolic activity on the other isomer. A fermentation or bioconversion process using this microorganism or the cell-free enzymes derived therefrom for the biological resolution of a racemic mixture of (R)- and (S)-baclofen and structurally related compounds is also disclosed.
L'invention concerne la production biologique de baclofen-d essentiellement pur et de composés structurellement apparentés, à partir du mélange racémique des isomères d et l du baclofen, de même que l'isolement dans la nature d'un microorganisme du genre Streptomyces. Ce microorganisme est capable de métaboliser de préférence un des isomères tout en exerçant une activité métabolique minimale sur l'autre. Un processus de fermentation ou de bioconversion à l'aide de ce microorganisme ou des enzymes acellulaires qui en sont dérivés pour le dédoublement biologique d'un mélange racémique de baclofen-d et de baclofen-l et de composés structurellement apparentés est également dévoilé.
Groleau Denis
Levadoux Wayne
Lortie Robert
Trani Michael
Anderson J. Wayne
Groleau Denis
Levadoux Wayne
Lortie Robert
National Research Council Of Canada
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