Stress proteins

Details Stress proteins Stress proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2191903

A polypeptide obtainable by inducement under hypoxic conditions having a sequence comprising: (a) the amino acid sequence of SEQ ID NO:1 or 3 or a fragment thereof; (b) an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 2 or 4 or a fragment thereof; or (c) an amino acid sequence resulting from deletion, addition, insertion or substitution of one or more amino acids in the amino acid sequence of SEQ ID NO:1 or 3; a polynucleotide encoding the above polypeptide or the fragment thereof useful for producing the above polypeptide by a biotechnological technique; and an antibody or fragment thereof specifically binding the above polypeptide.

olypeptide que l'on peut obtenir par stimulation sous conditions hypoxiques. L'une de ses séquences comprend : (a) la séquence d'acides aminés SEQ ID NO : 1 ou 3 ou un fragment de celle-ci; (b) une séquence d'acides aminés codant pour la séquence nucléotidique SEQ ID NO : 2 ou 4, ou un fragment de celle-ci ; ou (c) une séquence d'acides aminés résultant de la suppression, de l'ajout, de l'insertion ou de la substitution d'un ou de plusieurs acides aminés de la séquence d'acides aminés SEQ ID NO : 1 ou 3; un polynucléotide codant pour le polypeptide ci-dessus ou un fragment de celui-ci utile pour la production de ce polypeptide par une technique de biotechnologie; et un anticorps ou un fragment de celui-ci liant spécifiquement ce polypeptide.

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