Strictly alternating poly(alkylene oxide ether) copolymers

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 65/32 (2006.01) A61K 47/48 (2006.01) C08G 64/12 (2006.01) C08G 65/331 (2006.01) C08G 69/44 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2308520

Polyether copolymers characterized by strictly alternating poly(alkylene oxide) and aromatic diol monomeric repeating units, wherein the combination of repeating units is effective to provide the polyether with a hydrophilic/hydrophobic ratio at which aqueous micelle self-assembly occurs. Stable aqueous dispersions of hydrophobic drugs are also disclosed, as well as medical implants and drug delivery devices for implantation.

L'invention porte sur des copolymères polyéther caractérisés par une alternance stricte de motifs répétés de poly(alkylène oxyde) et de monomère diol aromatique. La combinaison des motifs répétés est efficace pour produire le polyéther avec un rapport hydrophile/hydrophobe dans lequel interviendra l'auto-assemblage de micelles aqueuses. L'invention porte également sur des dispersions aqueuses stables de médicaments hydrophobe, ainsi que sur des implants médicaux et sur des dispositifs d'administration de médicaments destinés à être utilisés dans les implantations.

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