Stroma derived predictor of breast cancer

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/71 (2006.01) C07K 14/72 (2006.01) C12N 15/16 (2006.01) C12N 15/18 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01) C40B 40/08 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2699434

The invention provides methods and compositions for use in the diagnosis and management of cancer, particularly breast cancer. The invention utilizes differential gene expression profiles in tumor associated stroma and normal stroma to compile a stroma derived prognostic predictor that classifies breast cancer patients according to clinical outcome. The application provides nucleic acids, antibodies, mircroarray chips and kits for use with the methods described in the application.

L'invention concerne des procédés et des compositions destinés à être utilisés dans le diagnostic et la prise en charge du cancer, en particulier le cancer du sein. L'invention utilise des profils d'expression génétique différentielle de stroma associé à une tumeur et de stroma normal, afin d'établir un indicateur pronostique dérivé du stroma qui classifie les patients atteints d'un cancer du sein en fonction du résultat clinique. La présente demande de brevet concerne des acides nucléiques, des anticorps, des puces à ADN et des kits destinés à être utilisés avec les procédés décrits dans la demande de brevet.

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