Structural basis for pterin function in nitric oxide synthase

Details Structural basis for pterin function in nitric oxide synthase Structural basis for pterin function in nitric oxide synthase

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C12N 9/02 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2361196

This invention describes methods and elucidates the three dimensional structure of nitric oxide synthase and its variants. Also described are methods of structural analysis to determine the binding of pterin to endothelial nitric oxide synthase and methods for screening and identifying small molecule modulators of endothelial nitric oxide synthase proteins and their variants. The invention also describes methods for identifying drugs that modulate nitric oxide synthase and its variants and are effective against diseased states in which NO signaling is defective or insufficient.

Cette invention concerne des méthodes permettant d'élucider la structure tridimensionnelle de l'oxyde nitrique synthase et de ses variantes. Elle porte également sur des techniques d'analyse structurelle visant à déterminer la liaison de la ptérine à l'oxyde nitrique synthase endothéliale et à identifier de petites molécules modulatrices de protéines d'oxyde nitrique synthase endothéliale et de leurs variantes. Sont également décrites des méthodes permettant d'identifier des médicaments qui modulent l'oxyde nitrique synthase et ses variantes et sont efficaces contre des états pathologiques caractérisés par une signalisation NO défectueuse ou insuffisante.

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