Structural models for cytoplasmic domains of transmembrane...

Details Structural models for cytoplasmic domains of transmembrane... Structural models for cytoplasmic domains of transmembrane...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2374133

Polypeptides containing a series of heptad-repeats that mimic a transmembrane domain and a selected cytoplasmic domain attached to the series of heptad repeats are provided which can be used in construction of structural models for evaluating the structure and activity of occupied and clustered transmembrane proteins and identifying therapeutic compounds.

L'invention concerne des polypeptides contenant une série de séquences d'heptade répétées imitant un domaine transmembranaire et un domaine cytoplasmique sélectionné attaché à la série de séquences d'heptade répétées. Lesdits polypeptides peuvent être utilisés dans la construction de modèles structuraux pour l'évaluation de la structure et de l'activité de protéines transmembranaires groupées et occupées et pour l'identification de composés thérapeutiques.

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