C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2504701
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers has a non-linear secondary structure or is part of a multiple oligomer assembly. Oligonucleotide/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein the oligomer has has a non-linear secondary structure or is part of a multiple oligomer assembly.
La présente invention concerne des compositions d'oligomères comprenant un premier et un second oligomère, une partie au moins de ce premier oligomère étant capable de s'hybrider avec au moins une partie de ce second oligomère, une partie de ce premier oligomère étant complémentaire d'un acide nucléique cible et capable de s'hybrider avec cet acide et, ce premier oligomère et/ou ce second oligomère possèdent une structure secondaire non linéaire ou font partie d'un ensemble d'oligomères multiples. Cette invention concerne aussi des compositions oligonucléotide/protéine comprenant un oligomère complémentaire d'un acide nucléique cible sélectionné et capable de s'hybrider avec cet acide et, au moins une protéine comprenant au moins une partie d'un complexe de dégradation induite par ARN (RISC), cet oligomère possédant une structure secondaire non linéaire ou faisant partie d'un ensemble d'oligomères multiples.
Boswell Herb
Crooke Stanley T.
Ecker David J.
Isis Pharmaceuticals Inc.
Smart & Biggar
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