C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/70 (2006.01) A61K 31/496 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 25/36 (2006.01) C07D 209/42 (2006.01) C07D 213/56 (2006.01)
Patent
CA 2498936
A family of structurally rigid dopamine D3 receptor selective ligands is described. The family of structurally rigid dopamine D3 receptor selective ligands has the formula wherein A is cis or trans -CH=CH-, -C=C-, or cyclohexyl. B is cis or trans -CH=CH- or absent.R1 represents an optionally substituted phenyl group, wherein said substituents are selected from the group consisting of: hydrogen, halogen, amino, nitro, hydroxyl, alkoxy, alkyl, acyl and pyridyl, and said substitution may occur at any of the ortho, meta, or para positions, or R1 represents a heteroaromatic ring. A preferred heteroaromatic ring is indole, quinoxoline, pyridyl, pyrimidyl, or imidazole. R2 and R3 may be independently hydrogen or a halogen, or R2 alone may be C1, C2, or C3 alkoxy, and m is 1 or 2, and n is 0, 1, or 2.
L'invention concerne une famille de ligands sélectifs en récepteur de dopamine D3 à structure rigide, de formule (I). Dans cette formule, A est cis ou trans CH=CH-, -C.ident.C-, ou cyclohexyle. B est cis ou trans CH=CH- ou absent. R¿1? est un groupe phényle éventuellement substitué, les substituants appartenant au groupe suivant: hydrogène, halogène, amino, nitro, hydroxyle, alcoxy, alkyle, acyle et pyridyle, et la substitution pouvant intervenir en l'une quelconque des positions ortho, méta, ou para, ou bien R¿1 ?est un chaîne hétéroaromatique, de préférence indole, quinoxoline, pyridyle, pyrimidyle, ou imidazole. R¿2? et R¿3? peuvent être indépendamment hydrogène or un halogène, ou bien R¿2? seul peut être C¿1?, C¿2?, ou C¿3? alcoxy, m vaut 1 ou 2, et n vaut 0, 1, ou 2.
Grundt Peter
Luedtke Robert R.
Newman Amy
Gov't Of The Usa As Represented By The Secretary Of The Departme
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Structurally rigid dopamine d3 receptor selective ligands... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Structurally rigid dopamine d3 receptor selective ligands..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Structurally rigid dopamine d3 receptor selective ligands... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1748516