C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 30/04 (2006.01) C12Q 1/68 (2006.01) C40B 20/08 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2526690
The present invention includes composition and methods for making and using a combinatorial library to identify modified thioptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL- 6, NF-KB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
L'invention concerne une composition et des procédés pour fabriquer et utiliser une bibliothèque combinatoire permettant d'identifier des thioptamères modifiés, qui lient et modifient la réponse immunitaire d'un animal hôte, des facteurs de transcription tels que IL-6, NF-<SB>K</SB>B, AP-1 et analogues. L'invention concerne également des compositions et des procédés pour traiter des infections virales, ainsi que des vaccins, et des adjuvants de vaccins, ceux-ci permettant de modifier les réponses immunitaires des hôtes.
Gorenstein David G.
Leary James
Luxon Bruce A.
Board Of Regents - The University Of Texas System
Shapiro Cohen
LandOfFree
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