A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01)
Patent
CA 2526853
The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the innune response of a host animal, transcription factors such as IL- 6, NF-kB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
L'invention concerne une composition et des procédés de fabrication et d'utilisation d'une banque combinatoire pour identifier les thioaptamères modifiés qui se lient à des facteurs de transcription tels que IL-6, NF-.kappa.B, AP-1 et analogue, et agissent sur la réponse immunitaire d'un animal hôte. L'invention concerne aussi une composition et des méthodes de traitement d'infections virales, ainsi que des vaccins et des adjuvants vaccinaux qui modifient les réponses immunitaires de l'hôte.
Aronson Judith F.
Barrett Allan
Beasley David
Gorenstein David G.
Herzog Norbert K.
Board Of Regents - The University Of Texas System
Shapiro Cohen
LandOfFree
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