C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/26 (2006.01) A61K 31/70 (2006.01) C07H 3/04 (2006.01) C07H 13/06 (2006.01) C07H 15/04 (2006.01) C12P 19/28 (2006.01) C12P 19/44 (2006.01)
Patent
CA 2184283
A purified lipid A from Rhizobium leguminosarum biovar phaseoli CE3, as well as analogs and derivatives of the purified lipid A are provided. Compositions containing heterogenous mixtures of lipid A from R. leguminosarum bv. phaseoli CE3 are also provided. The lipid A provided herein can be combined with a pharmaceutically acceptable carrier. Methods of stimulating the immune system in a subject, treating or preventing toxic shock in a subject, and methods of treating and preventing a lipopolysaccharide mediated disorder in a subject using the novel lipid A are provided.
L'invention concerne un lipide A purifié provenant de Rhizobium leguminosarum biovar phaseoli CE3, ainsi que ses analogues et dérivés. Elle porte aussi sur des compositions contenant des mélanges hétérogènes de lipide A provenant de Rhizobium leguminosarum biovar phaseoli CE3. Le lipide A en question peut être combiné avec un support acceptable du point de vue pharmaceutique. Il est également question de techniques permettant de stimuler le système immunitaire, de traiter et de prévenir les chocs toxiques, et de techniques permettant de traiter et de prévenir les troubles à médiation lipopolysacchararidique en utilisant le nouveau lipide A.
Gowling Lafleur Henderson Llp
University Of Georgia Research Foundation Inc.
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