Structure of secretory immunoglobulin a

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 14/25 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2269757

A secretory IgA antibody (sIgA) comprising a polymeric IgA antibody bound to a secretory component (SC) which SC comprises a (poly)peptide insert corresponding to a protective epitope of an antigen; a vaccine comprising such sIgA antibody; a DNA construct comprising a DNA sequence coding for a SC and a DNA insert coding for the protective epitope of an antigen; a method for producing said sIgA antibody; and a method for active immunization of a mammal which comprises administering to said mammal an effective amount of a vaccine comprising said sIgA.

L'invention concerne un anticorps sécrétoire IgA comprenant un anticorps IgA polymère lié à un composant sécrétoire comprenant lui-même un insert (poly)peptidique correspondant à un épitope protecteur d'un antigène; un vaccin comprenant de tels anticorps sécrétoires IgA; un ADN de recombinaison comprenant une séquence d'ADN codant pour un composant sécrétoire ou un insert d'ADN codant pour l'épitope protecteur d'un antigène; un procédé de préparation dudit anticorps sécrétoire IgA; et un procédé d'immunisation active d'un mammifère consistant à administrer audit mammifère une dose efficace d'un vaccin comprenant ledit anticorps sécrétoire d'IgA.

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