Structure of the insulin receptor ectodomain

Details Structure of the insulin receptor ectodomain Structure of the insulin receptor ectodomain

C - Chemistry, Metallurgy

07

K

C07K 14/72 (2006.01) G06F 19/16 (2011.01) A61K 45/00 (2006.01) C07K 19/00 (2006.01) C30B 29/58 (2006.01) C40B 30/02 (2006.01) C40B 30/04 (2006.01) G01N 23/20 (2006.01) G01N 33/68 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2655379

The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.

La présente invention concerne la structure cristalline de l'ectodomaine du récepteur de l'insuline, la nature de ses glycanes N-liés et des procédés d'utilisation des informations cristallines et structurales apparentées pour cribler et concevoir des composés qui interagissent ou modulent le récepteur de l'insuline et/ou les récepteurs de facteur de croissance analogue à l'insuline étroitement apparentés ou des variants de ceux-ci.

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