C - Chemistry – Metallurgy – 11 – C
Patent
C - Chemistry, Metallurgy
11
C
C11C 3/04 (2006.01) A23L 1/30 (2006.01) A61K 31/23 (2006.01) A61K 31/232 (2006.01) C07C 69/587 (2006.01)
Patent
CA 2151820
There is disclosed structured lipid containing either a gamma-linolenic acid or a dihomogamma linolenic acid residue, together with an n-3 fatty acid residue and a medium chain fatty acid residue on the same glycerol backbone. This structured lipid is particularly well adapted to the treatment of disease or stress states. The gamma-linolenic or dihomogamma-linolenic acid residues modify the prostanoid synthesis pathway, reducing the level of series "2" prostanoids and elevating the levels of series "1" and "3" prostanoids. The n-3 fatty acid residue enhances the level of series "1" prostanoids as well as increases the production of series "3" prostanoids. The medium chain fatty acid residues enhances the absorption of the structured lipid. There is also disclosed enteral and parentetal diets as well as nutritional supplements containing the structured lipids of the invention.
L'invention se rapporte à un lipide structuré contenant soit un reste d'acide gamma-linolénique ou d'acide dihomogamma-linolénique, ainsi qu'un reste d'acide gras n-3 et un reste d'acide gras à chaîne moyenne sur le même squelette de glycérol. Ce lipide structuré convient particulièrement au traitement d'états pathologiques ou associés au stress. Les restes d'acide gamma-linolénique ou dihomogamma linolénique modifient la voie de synthèse de prostanoïde en réduisant le niveau de prostanoïdes série "2" et en augmentant le niveau de prostanoïdes série "1" et "3". Le reste d'acide gras n-3 accroît le niveau des prostanoïdes série "1" ainsi que la production de prostanoïdes série "3". Les restes d'acide gras à chaîne moyenne accroissent l'absorption du lipide structuré. L'invention se rapporte également à des régimes entériques et parentéraux, ainsi qu'à des compléments alimentaires contenant les lipides structurés de l'invention.
Bistrian Bruce Ryan
Demichele Stephen Joseph
Karlstad Michael Donald
Mascioli Edward Anthony
Abbott Laboratories
New England Deaconess Hospital Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of Tennessee Research Corporation
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