Structured surfaces with properties which inhibit cell...

Details Structured surfaces with properties which inhibit cell... Structured surfaces with properties which inhibit cell...

C - Chemistry, Metallurgy

12

M

C12M 3/00 (2006.01) A01N 25/34 (2006.01) B29C 59/00 (2006.01) B29C 59/02 (2006.01) C12N 5/00 (2006.01) C12N 11/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2323719

Disclosed are articles having structured (i.e., rough) surfaces which inhibit proliferation and adhesion of eukaryotic cells such as fibroblasts. The structured surfaces have elevations with an average height of from 50 nm to 10 µm and an average separation of from 50 nm to 10 µm, and are made of materials having a surface energy of at least 20 mN/m as measured in an unstructured (i.e., smooth) form. The structured surfaces may be produced by a variety of processes such as an embossing process and the articles may be used e.g. as cell-culture vessels.

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