A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 31/56 (2006.01)
Patent
CA 2145584
This invention is concerned with a new transdermal matrix system for the percutaneous administration of a hormone, said matrix system, which has a support and a self-adhesive matrix, comprising a matrix containing: (a) 20 to 42 parts by weight of a poly(styrene-isoprene- styrene) triblock copolymer, (b) 35 to 55 parts by weight of a tackifying resin. (c) 5 to 25 parts by weight of a plasticizing agent selected from the group consisting of oleic alcohol, peglicol 5- oleate, propyleneglycol laurate or a polypropoxyl ether of cetyl alcohol, (d) 5 to 15 parts by weight of at least one compound selected from the group consisting of: - crotamiton, and - N-substituted 2-pyrrolidones of formula I, Image (I) wherein R represents a (C1-C15)-alkyl, cyclohexyl or 2- hydroxyethyl group, (e) 0,01 to 1 part by weight of a stabilizing agent and, (f) 0,1 to 5 parts by weight of a hormone selected from the group consisting of oestrogen components, progestogen components and mixtures thereof. It also relates to a method for prepararing said system.
Dhuique-Mayer Daniel
Liorzou Laurent
Mikler Claude
Laboratoires D'hygiene Et de Dietetique
Swabey Ogilvy Renault
LandOfFree
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