C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/55 (2006.01) A61K 31/195 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07C 235/74 (2006.01) C07D 213/30 (2006.01) C07D 213/32 (2006.01) C07D 213/40 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 215/233 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2046563
Abstract styryl compound of the formula(I): (I) Image wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt or an ester thereof is disclosed. Since the compounds of the present invention possess potent and long-lasting leukotriene-antagonistic actions and inhibitory actions against leukotriene, and exhibit better absorption by the oral administration. Further, the compounds of the present invention possess 5- lipoxygenase-inhibitory actions and/or cyclooxygenase- inhibitory actions, inhibitory actions to biosynthesis of LTB4, chemotactic actions against human leucocyte, chymase-inhibitory actions, inhibiyory actions to release of histamine or anti- histamine actions. Therefore, they are useful as the prophylactic and therapeutic medicines for brochial asthma, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic arthritis, allergic conjunctivitis, hay fever, urticaria, alimentary allergy, pain, pyretolysis, rheumatoid, thrombosis, coronary vascular diseases, ischemic heart disease, peptic or duodenal ulcer and the like.
Hamasaki Toshio
Kawakami Minoru
Konishi Mitsuhiro
Terasawa Michio
Fetherstonhaugh & Co.
Hamasaki Toshio
Kawakami Minoru
Konishi Mitsuhiro
Terasawa Michio
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