C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/24 (2006.01) A61K 31/235 (2006.01) A61K 31/395 (2006.01) C07C 43/243 (2006.01) C07C 43/247 (2006.01) C07C 43/253 (2006.01) C07C 65/26 (2006.01) C07C 69/94 (2006.01) C07D 213/30 (2006.01) C07D 213/36 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/89 (2006.01) C07D 233/64 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2129040
Compounds of general formula (1) are described, wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R6)-, where R6 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 and R4, which may be the same or different, is each a group -(CH2)n Ar, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1, 2 or 3; R5 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are pout, selective and orally active PDE IV inhibitors and are useful in the prophylaxis and treatment of asthma and other diseases.
Alexander Rikki Peter
Boyd Ewan Campbell
Warrellow Graham John
Celltech Limited
Celltech Therapeutics Limited
Kirby Eades Gale Baker
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