Styryl derivatives, their preparation and use as pde-iv...

Details Styryl derivatives, their preparation and use as pde-iv... Styryl derivatives, their preparation and use as pde-iv...

C - Chemistry, Metallurgy

07

D

C07D 213/24 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 255/37 (2006.01) C07C 255/43 (2006.01) C07D 207/337 (2006.01) C07D 213/30 (2006.01) C07D 213/55 (2006.01) C07D 213/57 (2006.01) C07D 213/61 (2006.01) C07D 233/28 (2006.01) C07D 233/68 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2135479

Compounds of general formula (1) are described (see formula 1) wherein Y is a halogen atom or a group -OR1, wherein R1 is C1-13 alkyl group which is either unsubstituted or substituted with one or more halogen atoms; X is -O-, - S-, or -N(R6), wherein R6 is a hydrogen atom or C1-6 alkyl group; R2 is C3-8 cycloalkyl or C3-8 cycloalkenyl group either unsubstituted or substituted with up to three substituents of specific types; R3 and R4, which may be the same or different, is each a hydrogen atom or C1-6 alkyl (optionally substituted with substituents of specific types), - CN, -CH2CN, -CO2R7, -CONR8R9 or CSNR8R9 (wherein R7, R8 and R9 represent groups of a specific type); Z is -(CH2)n- where n is zero or an integer 1, 2 or 3; R5 is a C6-12 monocyclic or bicyclic aryl group or a C1-9 monocyclic or bicyclic heteroaryl group containing up to four heteroatoms, the aryl group being either unsubstituted or substituted with up to four substituents of specific types; or a salt, solvate, hydrate, or N-oxide thereof. Compounds according to the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.

Affiliated with

Also associated with

Rating

Styryl derivatives, their preparation and use as pde-iv... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Styryl derivatives, their preparation and use as pde-iv..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Styryl derivatives, their preparation and use as pde-iv... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2018748