Subcutaneous implants releasing an active principle over an...

Details Subcutaneous implants releasing an active principle over an... Subcutaneous implants releasing an active principle over an...

A - Human Necessities

61

K

A61K 9/00 (2006.01)

Patent

CA 2659440

Subcutaneous implants obtained by extrusion containing an active ingredient dispersed in a PLGA matrix obtained by grinding an extruded product consisting of a blend of: at least two PLGA having different lactic acid/glycolic acid molar ratios and different weight average molecular weights, or a PLGA and PLA having different weight average molecular weight.

La présente invention concerne des implants sous-cutanés qui sont obtenus par extrusion et qui contiennent une matière active dispersée dans une matrice de PLGA obtenue en broyant un produit extrudé consistant en un mélange d'au moins deux PLGA ayant des rapports molaires acide lactique/acide glycolique différents et des masses moléculaires moyennes en poids différentes, ou un PLGA et un PLA ayant des masses moléculaires moyennes en poids différentes.

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