C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2389676
The present inventions relates to substances which are capable of controlling the inclusion of exon (10) of the tau gene. The substances can reverse "wrong" tau splicing pattern and. Since "wrong" tau splicing patterns are associated with tauopathies that cause dementia, the substances can be used as therapeutic agents. The invention also provides a method for testing substances that control tau exon (10) inclusion. The method is suitable for a high throughput screening. Additional products which are useful for changing tau exon (10) expression or for performing the test method are described as well.
La présente invention concerne des substances capables de commander l'inclusion de l'exon 10 du gène tau. Les substances de l'invention sont capables d'inverser le motif d'épissage tau <= incorrect >= et, étant donné que les motifs d'épissage tau <= incorrects >= sont associés aux tauopathies entraînant la démence, ces substances peuvent être utilisées comme agents thérapeutiques. L'invention concerne également un procédé permettant de tester des substances qui commandent l'inclusion de l'exon 10 du tau. Le procédé de l'invention est adapté au criblage à haut rendement. L'invention se rapporte également à des produits supplémentaires qui sont utilisés pour modifier l'expression de l'exon 10 du tau ou pour mettre en oeuvre le procédé d'essai de l'invention.
Andreadis Athena
Goedert Michel
Hartmann Annette
Stamm Stefan
Stoilov Peter
G. Ronald Bell & Associates
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
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