Substance dependence treatment using opiate antagonists and...

A - Human Necessities – 61 – K

Patent

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A61K 31/44 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2290788

Patients are treated for alcohol, marijuana, cocaine, opiate and polysubstance dependency by administration of combination of an effective amount of an opioid antagonist such as nalmefene, naloxone, naltrexone, or a mixture of any of these, and a serotonergic medication, such as sertraline, fluoxetine, paroxetine, fluvoxamine, or odansetron. Administration of an effective amount of an opioid antagonist alone helps to prevent relapse after detoxification is complete, and addition of the serotonergic medication increases the effectiveness, decreases the side effects of the opioid antagonist, and also helps relieve effects of withdrawal.

L'invention porte sur un traitement de la dépendance de patients vis à vis de l'alcool, de la marijuana, de la cocaïne, des opiacés, consistant à leur administrer une combinaison d'une quantité efficace d'un antagoniste des opiacés tel que la nalméfène, la naloxone, la naltréxone ou un de leurs mélanges, et une médication sérotonergique de sertraline, de fluoxétine, de paroxétine, de fluvoxamine ou d'odansétron. L'administration d'une quantité efficace d'un antagoniste des opiacés seule aide à prévenir les rechutes une fois la désintoxication achevée, tandis que l'adjonction de la médication sérotonergique accroît l'efficacité des antagonistes des opiacés, tout en en réduisant les effets secondaires et en contribuant à atténuer les effets du sevrage.

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