C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A61K 38/05 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2217729
Substance FA-70D which has the following formula (1). or its salt, a method for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating osteoporosis which comprises administering the compound, use of the compound as a drug, and a microorganism capable of producing Substance FA-70D. Image This compound has specific inhibitory activity against cathepsin series proteases and is of value as a therapeutic drug for various diseases with which these enzymes are associated, particularly osteoporosis.
Cette invention se rapporte à la substance FA-70D représentée par la formule (1) et à des sels de cette substance, à une composition médicinale contenant ce composé en tant qu'ingrédient actif, à un procédé de traitement de l'ostéoporose consistant à administrer ce composé, à l'utilisation de ce composé dans des médicaments et à un micro-organisme capable de produire ladite substance. Ce composé présente une activité inhibitrice spécifique dirigée contre les cathepsines et il s'avère utile en tant que médicament pour le traitement de diverses maladies mettant en jeu lesdits enzymes, et notamment de l'ostéoporose.
Katsunuma Nobuhiko
Kitano Shizuo
Otani Toshio
Sasaki Toru
Wu Yun
Marks & Clerk
Taiho Pharmaceutical Co. Ltd.
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