Substance mk7634, process for production thereof, and...

C - Chemistry – Metallurgy – 12 – P

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C12P 1/02 (2006.01) C07G 99/00 (2009.01) A61K 35/74 (2006.01) A61K 38/03 (2006.01) C07K 4/06 (2006.01)

Patent

CA 2205420

An imperfect fungus such as a microorganism belonging to the genus Curvularia in a culture medium containing nutrients utilizable for normal microorganisms and isolating MK7634 substance of a molecular formula: C8H15N3O4 from the culture by, for example, solvent extraction, ion exchange resin technique or gel filtration chromatography. The MK7634 substance can be used as an active ingredient of drugs. In particular, the MK7634 substance is a novel anthelmintic substance and expected to be used as an active ingredient of anthelmintics.

Procédé de production d'une substance MK7634 consistant à cultiver un champignon imparfait tel qu'un micro-organisme du genre Curvularia dans un milieu contenant des éléments nutritifs utilisables par un micro-organisme ordinaire et à isoler la substance cible de formule moléculaire C8H15N3O4 de la culture qui en résulte par extraction au solvant, par la technique de la résine échangeuse d'ions ou la chromatographie par perméation sur gel. Ladite substance peut être utilisée en tant qu'ingrédient actif dans des médicaments. En particulier, la substance MK7634 est une nouvelle substance à activité anthelmintique et elle est prometteuse en tant qu'ingrédient actif dans un médicament anthelmintique.

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