C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/22 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2405724
The present invention encompasses novel synthetic peptide analogs that are antagonists to Substance P, substance P like peptides and related peptides and are useful for the treatment of cancer. The invention particularly relates to the design and synthesis of the novel substance P antagonist analogs incorporating .alpha., .alpha.-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing these peptides and pharmacological applications of these peptides specifically in the treatment and prevention of cancer.
L'invention concerne des nouveaux analogues de peptides synthétiques qui sont des antagonistes de la substance P, des peptides de type de la substance P et des peptides associés, utiles dans le traitement du cancer. L'invention concerne en particulier la conception et la synthèse de la nouvelle substance P renfermant des acides aminés .alpha., .alpha.-dialkylés selon un mode spécifique à un site. L'invention concerne également des procédés de préparation de ces peptides, des compositions renfermant ces peptides et des applications pharmacologiques de ces peptides, notamment dans le traitement et la prévention du cancer.
Burman Anand C.
Jaggi Manu
Mukherjee Rama
Prasad Sudhanand
Singh Anu T.
Dabur Pharma Ltd.
Dabur Research Foundation
Marks & Clerk
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