Substances causing differentiation

Details Substances causing differentiation Substances causing differentiation

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2428161

The invention relates to a DNA construct that contains a fusion gene under the control of a promoter. The fusion gene comprises at least one resistance gene and at least one reporter gene and is slightly toxic to a host cell transfected with the DNA construct. The DNA construct can be encoded on a plasmid or a virus. The invention further relates to a method for using the DNA construct to identify substances that may induce differentiation in eukaryotic cells.

L'invention concerne une construction d'ADN contenant un gène de fusion sous le contrôle d'un promoteur. Ce gène de fusion comprend au moins un gène de résistance et au moins un gène rapporteur et il est toxique dans une faible mesure pour une cellule hôte transfectée avec la construction d'ADN. Cette construction d'ADN peut être codée sur un plasmide ou sur un virus. L'invention concerne également un procédé consistant à utiliser cette construction d'ADN pour identifier des substances qui peuvent déclencher une différenciation chez des cellules eucaryotes.

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