Substances k01-0509 and process for producing the same

Details Substances k01-0509 and process for producing the same Substances k01-0509 and process for producing the same

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) C12N 1/20 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2538293

A microorganism belonging to the genus Streptomyces and being capable of producing substance K01-0509-A1 and/or substance K01-0509-A2 is cultured in a medium. Then, the substance K01-0509-A1 and/or the substance K01-0509-A2 having been thus accumulated in the liquid culture medium are collected from the medium. It is expected that the obtained substances are efficacious as drugs which are selectively effective on pathogenic gram-negative bacteria having the type III secretion system.

Selon cette invention, un micro-organisme appartenant au genreStreptomyces et capable de produire la substance K01-0509-A1 et/ou la substance K01-0509-A2 est mis en culture dans un milieu. Ensuite, la substance K01-0509-A1 et/ou la substance K01-0509-A2 ainsi accumulée dans le milieu de culture liquide est recueillie à partir dudit milieu. Les substances ainsi obtenues sont susceptibles d'être efficaces en tant que médicaments qui agissent sélectivement sur la bactérie gram-négative pathogène comprenant le système de sécrétion de type III.

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