C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/00 (2006.01) C07F 15/02 (2006.01) C12N 1/20 (2006.01) C12P 9/00 (2006.01)
Patent
CA 2350913
The present invention relates to novel substance having inhibitory action on cholesteryl ester transfer protein. WK-5344A substance and WK-5344B substance, and process for production thereof. A microorganism belonging to genus Streptomyces having ability to produce WK-5344A substance and WK-5344B substance is cultured in a medium, and the WK-5344A substance and the WK-5344B substance are accumulated in the medium, then the WK-5344A substance and the WK-5344B substance are isolated from the said medium. Since the present substance shows significant inhibitory action on cholesteryl ester transfer protein, the substance is effective for prevention and treatment of diseases caused by accumulation of cholesterol in human.
L'invention concerne des nouvelles substances WK-5344A et WK-5344B inhibant la protéine de transfert d'ester de cholestéryle ; et un procédé de production desdites substances, qui consiste à mettre en culture un micro-organisme appartenant au genre Streptomyces et capable de produire les substances WK-5344A et WK-5344B dans un milieu, à accumuler ainsi les substances WK-5344A et WK-5344B dans le milieu de culture et à collecter lesdites substances dans ce dernier. En raison de leur activité inhibitrice puissante sur la protéine de transfert d'ester cholestéryle, ces substances sont utiles dans la prévention et le traitement de maladies d'humains induites par l'accumulation du cholestérol.
Omura Satoshi
Takahashi Yoko
Tomoda Hiroshi
Gowling Lafleur Henderson Llp
The Kitasato Institute
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