Substantially pure interleukin-9 receptor and uses thereof

Details Substantially pure interleukin-9 receptor and uses thereof Substantially pure interleukin-9 receptor and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2093145

The invention relates to substantially pure interleukin-9 receptor molecules, and the uses thereof. The molecule is a glycoprotein of about 64 kilodaltons and, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons. Figure 2 shows the binding of radioactive IL-9 to TS1 cells; which contain the IL-9 receptor, over time at various incubation temperatures. The substantially purified molecule can be used to inhibit the effect of IL-9 on an individual, to determine the amount of IL-9 in a sample, to determine the presence of cells which contain the IL-9 receptor, and to screen pharmaceuticals far efficacy in treating conditions characterized by excess proliferation of cells which proliferate in response to IL-9.

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